2 Won the Nobel Prize in Medicine for demonstrating our response to heat and touch-California News Times – mahrgan

On Monday, two scientists won the Nobel Prize in Medicine. This is about the discovery of how the human body perceives temperature and touch, which may lead to new ways to treat pain and heart disease. Americans David Julius and Aldem Patapoutian have respectively identified receptors on the skin that respond to heat and stress, and researchers are studying drugs against them. Some hope that these findings will eventually lead to treatment of pain and reduce dependence on highly addictive opioids. But the breakthrough that occurred decades ago has not yet created many effective new therapies. Julius of the University of California, San Francisco uses capsaicin, the active ingredient in peppers, to identify heat-responsive nerve sensors. The Nobel Committee said. Patapoutian of the Scripps Research Institute in La Jolla, California, discovered an intracellular pressure-sensitive sensor that responds to mechanical stimuli. “This really reveals one of nature’s secrets,” said Thomas Perlman, the secretary-general of the committee, when announcing the winner. “This is a very important and profound discovery because it is very important for our survival.” The committee said that their discovery is “one of the biggest mysteries facing humanity”, namely us. He said that it can be obtained by how you feel about the environment. The selection of the winners underscores how little scientists know about the problem before they discover it, and how much they still need to learn. Marlin, director of the MRC Neurodevelopmental Disorders Centre at King’s College London, said: “I can understand the physiology of the senses, but I cannot understand how I feel the difference in temperature and pressure.” “Understanding how our body perceives these changes is the most basic. Because knowing these molecules allows us to target them. It’s like finding a lock. Now I know the exact key needed to unlock it. “Marin may feel pain first, but scientists can reduce the pressure on blood vessels and other organs. . If you can understand how, understand how the body detects pressure changes that will eventually lead to medical treatments for heart disease. The Richard Harris Center for Chronic Pain and Fatigue Research at the University of Michigan also stated that the work of the new winners can help design new painkillers, but said the field has been stagnant for a long time. .. The body is not always enough to cope with it. Still, the work of Julius and Pataptian may help doctors better treat pain caused by extreme temperatures and chemical burns, he said. Many chronic pain patients have not been discovered. Despite this, Fiona Boysonade, a pain expert at the University of Sheffield, said that the Nobel Prize winner’s research is particularly relevant to one in five people in the world who suffer from chronic pain. She said arthritis, migraine and chronic back pain. Pain is “the main medical problem, and it is not fully treated at all.” “Their research may lead to the identification of new compounds that are effective in treating pain without the catastrophic effects of opioids. “This is to warn Nobel Prize winners of the long-standing difficulties. According to tradition, it caused an addiction crisis in the United States. Julius said he woke up shortly before the award, and he thought it was a prank call. “Numbers,” he said. Said from his home in San Francisco. It was already midnight there. It wasn’t a real joke until his wife heard Perlman’s voice and realized that he confirmed that he was the secretary of the committee. Julius said his wife Worked with Perlman many years ago. Julius, 65, later stated that he hoped his work would promote the development of new painkillers and explained that the biology behind daily activities may be very important. Bottom. How does this work.” The Nobel Committee tweeted a picture of Pataptian sleeping in bed, while his son was watching the announcement on the computer. Patapoutian was born in Lebanon and wrote on Twitter. Prestigious awards include a gold medal and 10 million Swedish kronor (over 1.14 million US dollars). The award is a bequest of the Swedish inventor Alfred Nobel, the creator of the award, who died in 1895. The award will be presented for the first time this year. Other awards are awarded for outstanding achievements in the fields of physics, chemistry, literature, peace and economics. ___ Chen is reported from London. Associated Press writer Frank Jordan is from Berlin.

On Monday, two scientists won the Nobel Prize in Medicine. The discovery of how the human body perceives temperature and touch has led to the discovery of new ways to treat pain and heart disease.

Americans David Julius and Aldem Patapoutian have identified different skin receptors that respond to heat and stress, and researchers are studying drugs against them. Some hope that these findings will eventually lead to treatment of pain and reduce dependence on highly addictive opioids. But the breakthrough that occurred decades ago has not yet created many effective new therapies.

According to the Nobel Committee, Julius of the University of California, San Francisco uses capsaicin, the active ingredient in peppers, to identify heat-responsive nerve sensors. Patapoutian of the Scripps Research Institute in La Jolla, California, discovered an intracellular pressure-sensitive sensor that responds to mechanical stimuli.

“This really reveals one of nature’s secrets,” said Thomas Perlman, the secretary-general of the committee, when announcing the winner. “This is a very important and profound discovery because it is very important to our survival.”

The committee stated that their findings are “one of the biggest mysteries facing humanity”, namely, how we feel about the environment.

Oscar Marine, director of the MRC Neurodevelopmental Disorders Center at King’s College London, emphasized that the winner’s choice is before the problem is discovered. Few scientists know the problem and how much they need to learn. bottom.

“We understand the physiology of the senses, but what we don’t understand is how we feel the difference in temperature and pressure,” Marin said. “Understanding how our body perceives these changes is essential, because knowing these molecules allows us to target them. It’s like finding a lock. Now I know the exact key needed to unlock it.”

Marin predicts that new pain treatments may appear first, but if scientists can understand how to reduce the pressure on blood vessels and other organs, how the body will detect changes in pressure. Understand the drugs that can ultimately lead to heart disease.

Richard Harris of the Center for Chronic Pain and Fatigue Research at the University of Michigan also said that the new winner’s research may help design new analgesics, but said the field has been stagnant for a long time.

He said that pain also has psychological factors, so determining how pain is caused in the body is not always sufficient to deal with it. Still, the work of Julius and Pataptian may help doctors better treat pain caused by extreme temperatures and chemical burns, he said.

“Their findings allowed us to understand for the first time how this type of pain started, but we still don’t know whether it is related to many chronic pain patients,” he said.

Despite this, Fiona Boissonnard, a pain expert at the University of Sheffield, said that the work of Nobel Prize winners is particularly relevant to one in five people in the world who suffer from chronic pain.

She said that pains such as arthritis, migraines and chronic back pain are “main medical problems and are not fully treated at all.” “Their research may lead to the identification of new compounds that are effective in treating pain without the catastrophic effects of opioids,” thereby triggering an addiction crisis in the United States.

For a long time, it has been difficult to warn Nobel Prize winners. Julius said that shortly before the award, he was awakened by a phone call that he thought was a prank.

He said from his home in San Francisco: “My phone made a beep. This is a relative contacted by someone from the Nobel Committee, trying to find my phone number.”

It wasn’t until his wife heard Perlman’s voice that he realized that when he confirmed that he was the secretary of the committee, it was not a real joke. Julius said his wife worked with Perlman years ago.

Julius, 65, later stated that he hoped his work would promote the development of new painkillers and explained that the biology behind daily activities may be very important. bottom.

“We eat chili and menthol, but usually we don’t think about how it works,” he said.

The Nobel Committee tweeted a photo of Patapoutian and his son in bed, while Pataptian was watching the announcement on his computer.

Patapoutian was born in Lebanon and said, “Thank you for the day. This country gives me the opportunity to get good education and support in basic research and my researchers and collaborators. They cooperate with me.”

Prestigious awards include a gold medal and 10 million Swedish kronor (over 1.14 million US dollars). The award is a bequest of the Swedish inventor Alfred Nobel, who was the creator of the award and died in 1895.

The award will be presented for the first time this year. Other awards are awarded for outstanding achievements in the fields of physics, chemistry, literature, peace and economics.

___

Chen reports from London. Associated Press writer Frank Jordan is from Berlin.

2 We won the Nobel Prize in Medicine for showing our reaction to heat and touch. 2 The Nobel Prize in Medicine was awarded for showing our reaction to heat and touch.

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